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Articles (99)
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High interstitial fluid pressure — an obstacle in cancer therapy

Heldin, Carl-Henrik, Rubin, Kristofer, Pietras, Kristian, Östman, Arne

Journal:

Nature Reviews Cancer

Année:

2004

Langue:

english

Fichier:

PDF, 227 KB

english, 2004

PDGF receptors as cancer drug targets

Kristian Pietras, Tobias Sjöblom, Kristofer Rubin, Carl-Henrik Heldin, Arne Östman

Journal:

Cancer Cell

Année:

2003

Langue:

english

Fichier:

PDF, 281 KB

english, 2003

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

Arne Östman, Martin Augsten

Journal:

Current Opinion in Genetics & Development

Année:

2009

Langue:

english

Fichier:

PDF, 352 KB

english, 2009

Production of cell-associated PDGF-AA by a human sarcoma cell line: evidence for a latent autocrine effect

Mozhgan Afrakhte, Monica Mistér, Arne Östman, Bengt Westermark, Ylva Paulsson

Journal:

International Journal of Cancer

Année:

1996

Langue:

english

Fichier:

PDF, 997 KB

english, 1996

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

Lene Uhrbom, Göran Hesselager, Arne Östman, Monica Nistér, Bengt Westermark

Journal:

International Journal of Cancer

Année:

2000

Langue:

english

Fichier:

PDF, 451 KB

english, 2000

Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling

Yoko Hasumi, Agnieszka Kłosowska-Wardęga, Masao Furuhashi, Arne Östman, Carl-Henrik Heldin, Carina Hellberg

Journal:

International Journal of Cancer

Année:

2007

Langue:

english

Fichier:

PDF, 391 KB

english, 2007

The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI

Simon P. Robinson, Christian Ludwig, Janna Paulsson, Arne Östman

Journal:

International Journal of Cancer

Année:

2008

Langue:

english

Fichier:

PDF, 506 KB

english, 2008

Metronomic scheduling of imatinib abrogates clonogenicity of neuroblastoma cells and enhances their susceptibility to selected chemotherapeutic drugs in vitro and in vivo

Ebba Palmberg, John Inge Johnsen, Janna Paulsson, Helena Gleissman, Malin Wickström, Margareta Edgren, Arne Östman, Per Kogner, Magnus Lindskog

Journal:

International Journal of Cancer

Année:

2009

Langue:

english

Fichier:

PDF, 267 KB

english, 2009

Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma

Janna Paulsson, Maja Bradic Lindh, Malin Jarvius, Marjut Puputti, Monica Nistér, Nina N. Nupponen, Werner Paulus, Ola Söderberg, Gregor Dresemann, Andreas von Deimling, Heikki Joensuu, Arne Östman, Ma

Journal:

International Journal of Cancer

Année:

2011

Langue:

english

Fichier:

PDF, 322 KB

english, 2011

Modulation of growth factor responsiveness of murine mammary carcinoma cells by cell matrix interactions: Correlation of cell proliferation and spreading

Bruce Elliott, Arne Östman, Bengt Westermark, Kristofer Rubin

Journal:

Journal of Cellular Physiology

Année:

1992

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1992

Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line

Flemming S. Vassbotn, Arne Östman, Nina Langeland, Holm Holmsen, Bengt Westermark, Carl-Henrik Heldin, Monica Nistér

Journal:

Journal of Cellular Physiology

Année:

1994

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1994

Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit

Aviv Gazit, Kevin Yee, Andrea Uecker, Frank-D Böhmer, Tobias Sjöblom, Arne Östman, Johannes Waltenberger, Gershon Golomb, Shmuel Banai, Michael C Heinrich, Alexander Levitzki

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 624 KB

english, 2003

Platelet Derived Growth Factor (PDGF) Responsive Epidermis Formed from Human Keratinocytes Transduced with the PDGFβ Receptor Gene

Rollman, Ola, Jensen, Uffe B, Östman, Arne, Bolund, Lars, Gústafsdóttir, Sigrún M, Jensen, Thomas G

Journal:

The Journal of Investigative Dermatology

Année:

2003

Langue:

english

Fichier:

PDF, 2.48 MB

english, 2003

A fluid cover medium provides superior morphology and preserves RNA integrity in tissue sections for laser microdissection and pressure catapulting

Patrick Micke, Tone Bjørnsen, Stefan Scheidl, Sara Strömberg, Jean-Baptiste Demoulin, Fredrik Ponten, Arne Östman, Per Lindahl, Christer Busch

Journal:

The Journal of Pathology

Année:

2004

Langue:

english

Fichier:

PDF, 690 KB

english, 2004

Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase

Sofi Forsberg, Arne Östman, Ola Rollman

Journal:

Archives of Dermatological Research

Année:

2008

Langue:

english

Fichier:

PDF, 645 KB

english, 2008

A Digest on the Role of the Tumor Microenvironment in Gastrointestinal Cancers

Martin Augsten, Christina Hägglöf, Cristina Peña, Arne Östman

Journal:

Cancer Microenvironment

Année:

2010

Langue:

english

Fichier:

PDF, 300 KB

english, 2010

Protein tyrosine phosphatases: regulatory mechanisms

Jeroen den Hertog, Arne Östman, Frank-D. Böhmer

Journal:

FEBS Journal

Année:

2008

Langue:

english

Fichier:

PDF, 414 KB

english, 2008

Analogous alternative splicing

BETSHOLTZ, CHRISTER, RORSMAN, FREDRIK, WESTERMARK, BENGT, ÖSTMAN, ARNE, HELDIN, CARL-HENDRIK

Journal:

Nature

Année:

1990

Fichier:

PDF, 129 KB

1990

10.1038/35074588

Bergsten, Erika, Uutela, Marko, Li, Xuri, Pietras, Kristian, Östman, Arne, Heldin, Carl-Henrik, Alitalo, Kari, Eriksson, Ulf

Journal:

Nature Cell Biology

Année:

2001

Langue:

english

Fichier:

PDF, 469 KB

english, 2001

Platelet-derived growth factor: Isoform-specific signalling via heterodimeric or homodimeric receptor complexes

Heldin, Carl-Henrik, Östman, Arne, Eriksson, Anders, Siegbahn, Agneta, Claesson-Welsh, Lena, Westermark, Bengt

Journal:

Kidney International

Année:

1992

Langue:

english

Fichier:

PDF, 472 KB

english, 1992

Biobanking of fresh frozen tissue: RNA is stable in nonfixed surgical specimens

Micke, Patrick, Ohshima, Mitsuhiro, Tahmasebpoor, Simin, Ren, Zhi-Ping, Östman, Arne, Pontén, Fredrik, Botling, Johan

Journal:

Laboratory Investigation

Année:

2006

Langue:

english

Fichier:

PDF, 648 KB

english, 2006

Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas

Nupponen, Nina N, Paulsson, Janna, Jeibmann, Astrid, Wrede, Brigitte, Tanner, Minna, Wolff, Johannes E A, Paulus, Werner, Östman, Arne, Hasselblatt, Martin

Journal:

Modern Pathology

Année:

2007

Langue:

english

Fichier:

PDF, 208 KB

english, 2007

Protein detection using proximity-dependent DNA ligation assays

Fredriksson, Simon, Gullberg, Mats, Jarvius, Jonas, Olsson, Charlotta, Pietras, Kristian, Gústafsdóttir, Sigrún Margrét, Östman, Arne, Landegren, Ulf

Journal:

Nature Biotechnology

Année:

2002

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2002

Protein-tyrosine phosphatases and cancer

Östman, Arne, Hellberg, Carina, Böhmer, Frank D.

Journal:

Nature Reviews Cancer

Année:

2006

Langue:

english

Fichier:

PDF, 477 KB

english, 2006

In Situ Identification of Genes Regulated Specifically in Fibroblasts of Human Basal Cell Carcinoma

Micke, Patrick, Kappert, Kai, Ohshima, Mitsuhiro, Sundquist, Christina, Scheidl, Stefan, Lindahl, Per, Heldin, Carl-Henrik, Botling, Johan, Ponten, Fredrik, Östman, Arne

Journal:

The Journal of Investigative Dermatology

Année:

2007

Langue:

english

Fichier:

PDF, 140 KB

english, 2007

Characterization of the chronic myelomonocytic leukemia associated TEL-PDGFβR fusion protein

Sjöblom, Tobias, Boureux, Anthony, Rönnstrand, Lars, Heldin, Carl-Henrik, Ghysdael, Jacques, Östman, Arne

Journal:

Oncogene

Année:

1999

Langue:

english

Fichier:

PDF, 364 KB

english, 1999

The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell–matrix adhesion

Jandt, Enrico, Denner, Karsten, Kovalenko, Marina, Östman, Arne, Böhmer, Frank-D

Journal:

Oncogene

Année:

2003

Langue:

english

Fichier:

PDF, 506 KB

english, 2003

Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases

Åsa Sandin, Markus Dagnell, Adrian Gonon, John Pernow, Verena Stangl, Pontus Aspenström, Kai Kappert, Arne Östman

Journal:

Cellular Signalling

Année:

2011

Langue:

english

Fichier:

PDF, 522 KB

english, 2011

Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2

Irene Weibrecht, Sylvia-Annette Böhmer, Markus Dagnell, Kai Kappert, Arne Östman, Frank-D. Böhmer

Journal:

Free Radical Biology and Medicine

Année:

2007

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2007

Hallmarks of cancer: Interactions with the tumor stroma

Kristian Pietras, Arne Östman

Journal:

Experimental Cell Research

Année:

2010

Langue:

english

Fichier:

PDF, 864 KB

english, 2010

Signal transduction via platelet-derived growth factor receptors

Carl-Henrik Heldin, Arne Östman, Lars Rönnstrand

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Année:

1998

Langue:

english

Fichier:

PDF, 609 KB

english, 1998

Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

Arne Östman, Frank-D Böhmer

Journal:

Trends in Cell Biology

Année:

2001

Langue:

english

Fichier:

PDF, 193 KB

english, 2001

Protein tyrosine phosphatase structure–function relationships in regulation and pathogenesis

Frank Böhmer, Stefan Szedlacsek, Lydia Tabernero, Arne Östman, Jeroen den Hertog

Journal:

FEBS Journal

Année:

2012

Langue:

english

Fichier:

PDF, 728 KB

english, 2012

The tumor microenvironment controls drug sensitivity

Östman, Arne

Journal:

Nature Medicine

Année:

2012

Langue:

english

Fichier:

PDF, 4.30 MB

english, 2012

New Members of the Platelet-Derived Growth Factor Family of Mitogens

Carl-Henrik Heldin, Ulf Eriksson, Arne Östman

Journal:

Archives of Biochemistry and Biophysics

Année:

2002

Langue:

english

Fichier:

PDF, 288 KB

english, 2002

Cultured Kaposi's sarcoma-derived cells express functional PDGF A-type and B-type receptors

Sabine Werner, Peter Hans Hofschneider, Carl-Henrik Heldin, Arne Östman, Willi Kurt Roth

Journal:

Experimental Cell Research

Année:

1990

Langue:

english

Fichier:

PDF, 2.44 MB

english, 1990

Identification of three amino acid residues in the B-chain of platelet-derived growth factor with different importance for binding to PDGF α- and β-receptors

Joachim Kreysing, Arne Östman, Monique van de Poll, Gudrun Bäckström, Carl-Henrik Heldin

Journal:

FEBS Letters

Année:

1996

Langue:

english

Fichier:

PDF, 294 KB

english, 1996

Ligand-induced dimerization of growth factor receptors: Variations on the theme

Carl-Henrik Heldin, Arne Östman

Journal:

Cytokine & Growth Factor Reviews

Année:

1996

Langue:

english

Fichier:

PDF, 760 KB

english, 1996

Regulation of tyrosine phosphatases in the adventitia during vascular remodelling

Patrick Micke, Daniel Hackbusch, Sibel Mercan, Philipp Stawowy, Oleg Tsuprykov, Thomas Unger, Arne Östman, Kai Kappert

Journal:

Biochemical and Biophysical Research Communications

Année:

2009

Langue:

english

Fichier:

PDF, 481 KB

english, 2009

Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”

Robert Karisch, Minerva Fernandez, Paul Taylor, Carl Virtanen, Jonathan R. St-Germain, Lily L. Jin, Isaac S. Harris, Jun Mori, Tak W. Mak, Yotis A. Senis, Arne Östman, Michael F. Moran, Benjamin G. Ne

Journal:

Cell

Année:

2011

Langue:

english

Fichier:

PDF, 2.88 MB

english, 2011

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma

Arne Östman

Journal:

Cytokine & Growth Factor Reviews

Année:

2004

Langue:

english

Fichier:

PDF, 356 KB

english, 2004

Profiling of Radicular Cyst and Odontogenic Keratocyst Cytokine Production Suggests Common Growth Mechanisms

Makoto Hayashi, Takafumi Ohshima, Mitsuhiro Ohshima, Yoko Yamaguchi, Hirofumi Miyata, Osamu Takeichi, Bunnai Ogiso, Koichi Ito, Arne Östman, Kichibee Otsuka

Journal:

Journal of Endodontics

Année:

2008

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2008

An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases

Camilla Persson, Kai Kappert, Ulla Engström, Arne Östman, Tobias Sjöblom

Journal:

Methods

Année:

2005

Langue:

english

Fichier:

PDF, 340 KB

english, 2005

Transgenic Overexpression of Platelet-Derived Growth Factor-C in the Mouse Heart Induces Cardiac Fibrosis, Hypertrophy, and Dilated Cardiomyopathy

Annica Pontén, Xuri Li, Peter Thorén, Karin Aase, Tobias Sjöblom, Arne Östman, Ulf Eriksson

Journal:

The American Journal of Pathology

Année:

2003

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2003

Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF β-receptor by the receptor-like protein tyrosine phosphatase DEP-1

Camilla Persson, Ulla Engström, Sherry L Mowbray, Arne Östman

Journal:

FEBS Letters

Année:

2002

Langue:

english

Fichier:

PDF, 141 KB

english, 2002

Stromal signature identifies basal breast cancers

Wennmalm, Kristian, Östman, Arne, Bergh, Jonas

Journal:

Nature Medicine

Année:

2009

Langue:

english

Fichier:

PDF, 258 KB

english, 2009

The effect of local anaesthetic agents on lipolysis by human adipose tissue

Peter Arner, Ored Arne, Jan Östman

Journal:

Life Sciences

Année:

1973

Langue:

english

Fichier:

PDF, 355 KB

english, 1973

Inhibitory DNA Ligands to Platelet-Derived Growth Factor B-Chain

Green, Louis S., Jellinek, Derek, Jenison, Robert, Östman, Arne, Heldin, Carl-Henrik, Janjic, Nebojsa

Journal:

Biochemistry

Année:

1996

Langue:

english

Fichier:

PDF, 676 KB

english, 1996

Prognostic Significance of Stromal Platelet-Derived Growth Factor β-Receptor Expression in Human Breast Cancer

Janna Paulsson, Tobias Sjöblom, Patrick Micke, Fredrik Pontén, Göran Landberg, Carl-Henrik Heldin, Jonas Bergh, Donal J. Brennan, Karin Jirström, Arne Östman

Journal:

The American Journal of Pathology

Année:

2009

Langue:

english

Fichier:

PDF, 920 KB

english, 2009

Involvement of Loop 2 of Platelet-Derived Growth Faetor-AA and-BB in Receptor Binding

Andersson, Maria, Östman, Arne, Kreysing, Joachim, Bäckström, Gudrun, van de Poll, Monique, Heldin, Carl-Henrik

Journal:

Growth Factors

Année:

1995

Langue:

english

Fichier:

PDF, 612 KB

english, 1995